کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5009896 | 1462046 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sensor array detection of malaria volatile signature in a murine model
ترجمه فارسی عنوان
تشخیص آرایه سنسور امضا فرار مالاریا در مدل موش
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کلمات کلیدی
مالاریا، ترکیبات فرار، سنسورهای گاز،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
On these bases, we investigated the alteration of volatile compounds in a malaria murine model. For the scope, the total “volatilome” of Plasmodium berghei-infected mice was compared with that of non-infected animals. Gas chromatographic analysis of the sampled air reveals the existence of a pattern of compounds that, collectively considered, detects malaria infection. Finally, an array of porphyrins functionalized quartz microbalance gas sensors was applied to sort non-infected from infected mice. The application of a classification model to the sensor data provided more than 80% of correct identification with errors confined to mice with a low parasitemia level. Noteworthy, the sensor array was trained on data collected months before to run the tests. These results provide, although limited to a murine model, a first evidence of the potentialities of gas sensor technology for malaria diagnosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 245, June 2017, Pages 341-351
Journal: Sensors and Actuators B: Chemical - Volume 245, June 2017, Pages 341-351
نویسندگان
Rosamaria Capuano, Ana Carolina Domakoski, Felicia Grasso, Leonardo Picci, Alexandro Catini, Roberto Paolesse, Giorgio Sirugo, Eugenio Martinelli, Marta Ponzi, Corrado Di Natale,