کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5020341 1469068 2018 10 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
A combined experimental, modeling, and computational approach to interpret the viscoelastic response of the white matter brain tissue during indentation
ترجمه فارسی عنوان
یک روش ترکیبی تجربی، مدلسازی و رویکرد محاسباتی برای تفسیر پاسخ ویسکوالاستیک از بافت مغز ماده سفید در طول اندام
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کلمات کلیدی
تنه مونوتونی؛ آسیب تروماتیک مغز؛ رفتار وابسته به نرخ؛ مدل سازی عنصر محدود
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی

Viscoelastic properties of the white matter brain tissue are systematically studied in this paper utilizing indentation experiments, mathematical modeling, and finite element simulation. It is first demonstrated that the internal stiffness of the instrument needs to be thoroughly obtained and incorporated in the analysis as its contribution to the recorded mechanical response is significant for experiments on very compliant materials. The flat-punch monotonic indentation is then performed indirectly on sagittal plane slices with pushing a large rigid coverslip into the sample surface. The recorded load and displacement data are used for calibrating different viscoelastic models and presenting numerical values for the model elements. Consequently, the accuracy of the findings based on the theoretical models is investigated by performing finite element simulations which suggest a considerable substrate effect that causes violation of the semi-infinite half-space assumption in modeling of the material behavior. Accordingly, correction factors for adjusting the viscoelastic constants are obtained and presented. Since the Maxwell model shows a superior capability in rendering the mechanical response of the brain, an extension of this model to Multimode Maxwell viscoelastic solid is proposed for modeling the tissue behavior under a more complex load-hold-unload indentation cycle that shows acceptable agreement with experimental observations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Mechanical Behavior of Biomedical Materials - Volume 77, January 2018, Pages 24-33
نویسندگان
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