کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5020422 | 1469071 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A numerical-experimental protocol to characterize corneal tissue with an application to predict astigmatic keratotomy surgery
ترجمه فارسی عنوان
یک پروتکل عددی آزمایشگاهی برای تشخیص بافت قرنیه با کاربردی برای پیش بینی جراحی کراتوتومی آستیگماتیسم
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کلمات کلیدی
بافت قرنیه، روش متناوب معکوس معکوس، مکانیک قرنیه، کراتوتومی آستیگماتیک، اپتیک قرنل،
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
چکیده انگلیسی
Tonometers are intended to determine the intraocular pressure (IOP) and the quality of corneal tissue. In contrast to the physiological state of stress of the cornea, tonometers induce non-physiological bending stress. Recently, the use of a single experiment to calibrate a set of corneal mechanical properties was suggested to be an ill-posed problem. Thus, we propose a numerical-experimental protocol that uses inflation and indentation experiments simultaneously, restricting the optimization space to circumvent the ambiguity of the fitting. For the first time, both corneal behaviors, i.e., biaxial tension (physiological) and bending (non-physiological), are taken into account. The experimental protocol was performed using an animal model (New Zealand rabbit's cornea). The patient-specific geometry and IOP were registered using a MODI topographer (CSO, Italy) and an applanation tonometer, respectively. The mechanical response was evaluated using inflation and indentation experiments. Subsequently, the optimal set of material properties is identified via an inverse finite element method. To validate the methodology, an in vivo incisional refractive surgery (astigmatic keratotomy, AK) is performed on four animals. The optical outcomes showed a good agreement between the real and simulated surgeries, indicating that the protocol can provide a reliable set of mechanical properties that enables further applications and simulations. After a reliable ex vivo database of inflation experiments is built, our protocol could be extended to humans.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Mechanical Behavior of Biomedical Materials - Volume 74, October 2017, Pages 304-314
Journal: Journal of the Mechanical Behavior of Biomedical Materials - Volume 74, October 2017, Pages 304-314
نویسندگان
M.Á. Ariza-Gracia, Á. Ortillés, J.Á. Cristóbal, J.F. RodrÃguez Matas, B. Calvo,