کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5020657 1469076 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mobility and shape adaptation of neutrophil in the microchannel flow
ترجمه فارسی عنوان
تحرک و شکل سازگاری نوتروفیل در جریان میکرو کانال
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی
This paper presents motion of neutrophil in a confined environment. Many experimental and theoretical studies were performed to show mechanics and basic principles of the white blood cell motion. However, they were mostly performed on flat plates without boundaries. More realistic model of flow in the capillaries based on confinement, curvature and adequate dimensions is applied in our experiments. These conditions lead to cell motion with deformability and three-dimensional character of that movement. Neutrophils are important cells for human immune system. Their motion and attachment often influence several diseases and immune response. Hence, studies focus on that particular cell type. We have shown that deformability of the cell influences its velocity. Cells actively participate in the flow using the shear gradient to advance control motion. The observed neutrophil velocity was from 1 up to 100μm/s.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Mechanical Behavior of Biomedical Materials - Volume 69, May 2017, Pages 294-300
نویسندگان
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