Impact of Recirculation in Dynamic Contrast-Enhanced Ultrasound: A Simulation Study

- Log-Normal model is sensitive to recirculation.
- Normalizing parameters according to a reference tissue reduces recirculation error.
- Fitting the earliest phase only yields inaccurate and imprecise parameters.
- Simulations confirm compartmental models are intrinsically insensitive to recirculation.
- The regularized compartmental model is the most promising investigated method.