کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5032238 1471112 2017 24 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Collective dynamics of cancer cells confined in a confluent monolayer of normal cells
ترجمه فارسی عنوان
دینامیک جمعی سلول های سرطانی در یک سلول مجزا از سلول های طبیعی محدود می شود
کلمات کلیدی
رشد تومور، حمله سرطانی، تحرک سلولی، پویایی سلولی جمعی،
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی
Tumorigenesis often involves specific changes in cell motility and intercellular adhesion. Understanding the collective cancer cell behavior associated with these specific changes could facilitate the detection of malignant characteristics during tumor growth and invasion. In this study, a cellular vertex model is developed to investigate the collective dynamics of a disk-like aggregate of cancer cells confined in a confluent monolayer of normal cells. The effects of intercellular adhesion and cell motility on tumor progression are examined. It is found that the stresses in both the cancer cells and the normal cells increase with tumor growth, resulting in a crowded environment and enhanced cell apoptosis. The intercellular adhesion between cancer cells and normal cells is revealed to promote tumor growth and invasion. The tumor invasion dynamics hinges on the motility of cancer cells. The cancer cells could orchestrate into different collective migration modes, e.g., directional migration and rotational oscillations, dictated by the competition between cell persistence and local coordination. Phase diagrams are established to reveal the competitive mechanisms. This work highlights the role of mechanics in regulating tumor growth and invasion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 52, 8 February 2017, Pages 140-147
نویسندگان
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