کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5032385 1369982 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhancing cell-free layer thickness by bypass channels in a wall
ترجمه فارسی عنوان
افزایش ضخامت لایه بدون سلول توسط کانال های بادی در یک دیوار
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی
When blood flows near a wall, red blood cells (RBCs) drift away from the wall and a cell-free layer (CFL) is formed adjacent to the wall. Controlling the CFL thickness is important for preventing adhesion of cells in the design of biomedical devices. In this study, a novel wall configuration with stenoses and bypass channels is proposed to increase the CFL thickness. We found that the presence of bypass channels modified the spatial distribution of cells and substantially increased the CFL downstream of the stenosis. A single-bypass geometry with 5% hematocrit (Hct) blood flow showed a 1.7μm increase in CFL thickness compared to without the bypass. In the case of three bypass channels, a 3μm increase in CFL thickness was observed. The CFL enhancement was observed up to 10% Hct, but no significant enhancement of CFL was indicated for 20% Hct blood flow. The mechanism of the CFL enhancement was investigated using a numerical simulation of the flow field. The results showed that the distance between each streamline and the corner of the stenosis compared with size of RBC was important parameter in regulating CFL thickness. These results show the potential of the proposed mechanism to prevent adhesion of cells to biomedical devices.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 49, Issue 11, 26 July 2016, Pages 2299-2305
نویسندگان
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