Towards the modelling of ageing and atherosclerosis effects in ApoE-/- mice aortic tissue

The results indicate that the aorta-stiffness of the healthy control mice remains basically constant irrespective of the diet-time and age. In contrast, significant differences exist within the material response and in consequence within the material parameters between the ApoE−/− and the control mice as well as for the different locations over the aorta which is underlined by our experimental observations. With regard to the temporal evolution of the material parameters, we observe that the material parameters for the ApoE−/− mice aortas exhibit a saturation-type increase with respect to age.