کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5039273 1473192 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum lipids and lifetime suicide attempts in patients with Obsessive-Compulsive Disorder
ترجمه فارسی عنوان
لیپید سرم و اقدام به خودکشی در طول عمر بیماران مبتلا به اختلال وسواسی-اجباری
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
چکیده انگلیسی


- Lifetime suicide attempt in patients with OCD is 8,7%.
- Serum lipids are altered in OCD patients with at least a suicide attempt.
- Lower HDL-c and higher triglycerides levels could have a potential role on suicidality risk.
- Metabolic syndrome has not any influence on suicidality.

The rate of suicide attempts in patients with Obsessive-Compulsive Disorder (OCD) is reported to be approximately 10%. Potential markers of suicidality, among which biological ones, have been identified. The aim of this naturalistic study is to evaluate the relationship between serum lipids levels and suicide attempts in patients with OCD. Subjects with a principal diagnosis of DSM-IV TR OCD and a YBOCS≥16 were included. Sociodemographic and clinical characteristics, serum lipids profile, body mass index were collected. One-hundred-four patients were included. Nine patients (8.7%) reported at least a lifetime suicide attempt. HDL cholesterol was significantly lower while triglycerides were higher in lifetime suicide attempters compared to the other group. No significant differences emerged between attempters and non-attempters in serum total cholesterol, other metabolic parameters or Metabolic Syndrome (MetS) rate. Our study provides further evidence of a potential role of metabolic parameters on suicidality: decreased HDL-C and increased triglycerides levels could be a trait marker of higher vulnerability to suicidality in patients with OCD. Further studies should be performed with a longitudinal design in order to explain this association.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Obsessive-Compulsive and Related Disorders - Volume 15, October 2017, Pages 1-6
نویسندگان
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