کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5040335 1473845 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Individual differences in early adolescents' latent trait cortisol: Interaction of early adversity and 5-HTTLPR
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Individual differences in early adolescents' latent trait cortisol: Interaction of early adversity and 5-HTTLPR
چکیده انگلیسی


- Greater early adversity was linked to lower latent trait cortisol (LTC).
- 5-HTTLPR moderated the association between early adversity and LTC.
- The inverse link of early adversity and LTC was larger among L-carriers of 5-HTTLPR.
- 5-HTTLPR may contribute to the variability in cortisol responses to adversity.

The present study aimed to examine the interaction of 5-HTTLPR and early adversity on trait-like levels of cortisol. A community sample of 117 early adolescent girls (M age = 12.39 years) provided DNA samples for 5-HTTLPR genotyping, and saliva samples for assessing cortisol 3 times a day (waking, 30 min post-waking, and bedtime) over a three-day period. Latent trait cortisol (LTC) was modeled using the first 2 samples of each day. Early adversity was assessed with objective contextual stress interviews with adolescents and their mothers. A significant 5-HTTLPR × early adversity interaction indicated that greater early adversity was associated with lower LTC levels, but only among individuals with either L/L or S/L genotype. Findings suggest that serotonergic genetic variation may influence the impact of early adversity on individual differences in HPA-axis regulation. Future research should explore whether this interaction contributes to the development of psychopathology through HPA axis functioning.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychology - Volume 129, October 2017, Pages 8-15
نویسندگان
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