کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5044217 1475362 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of single genetic variants and polygenic obesity risk scores on disordered eating in adolescents - The HUNT study
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Effects of single genetic variants and polygenic obesity risk scores on disordered eating in adolescents - The HUNT study
چکیده انگلیسی

PurposeImproving the understanding of the role of genetic risk on disordered eating (DE).MethodsA case-control study including 1757 (F: 979, M: 778) adolescents (aged 13-19 years) from the Nord-Trøndelag Health Study (HUNT), an ethnically homogenous Norwegian population based study. Cases and controls were defined using a shortened version of the Eating Attitude Test. Logistic regression was employed to test for associations between DE phenotypes and 24 obesity and eating disorder susceptibility SNPs, and the joint effect of a subset of these in a genetic risk score (GRS).ResultsCOMT was shown to be associated with poor appetite/undereating (OR: 0.6, CI 95%: 0.43-0.83, p = 0.002). Independent of obesity associations, the weighted GRS was associated to overeating in 13-15 year old females (OR: 2.07, CI 95%: 1.14-3.76, p = 0.017). Additionally, a significant association was observed between the GRS and loss of control over eating in the total sample (OR: 1.62, CI 95%: 1.01-2.61, p = 0.046).ConclusionsThe COMT variant (rs4680) was associated with poor appetite/undereating. Our study further confirms prior findings that obesity risk also confers risk for loss of control over eating; and overeating amongst girls.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Appetite - Volume 118, 1 November 2017, Pages 8-16
نویسندگان
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