Total PYY and GLP-1 responses to submaximal continuous and supramaximal sprint interval cycling in men

Exercise-induced changes in appetite-regulating hormones may be intensity-dependent, however a clear dose-response relationship has not been established. The purpose of this study was to examine changes in anorexigenic markers (total PYY and GLP-1) in response to rest or exercise at submaximal and supramaximal intensities. Ten active males completed four experimental sessions in randomized order: 1) Moderate intensity continuous training (MICT; 30 min cycling at 65% VO2max); 2) High intensity continuous training (HICT; 30 min cycling at 85% VO2max); 3) Sprint interval training (SIT; 6 × 30 s “all-out” cycling bouts with 4 min recovery periods); 4) Control (CTRL; no exercise). Blood samples were obtained immediately pre- and post-exercise, as well as 90-min post-exercise for the measurement of total PYY and GLP-1. Subjective hunger was assessed using a visual analog scale pre-breakfast and at the three blood sampling time-points. Total PYY concentrations increased immediately post-exercise following both HICT (P = 0.006) and SIT (P < 0.001) versus CTRL, while SIT was also greater (P = 0.005) compared to MICT. Total GLP-1 concentrations changed similarly across time-points (P < 0.001), with no differences between sessions (P = 0.280). Perceptions of hunger also changed similarly across time-points (P < 0.001) with no differences between trials (P = 0.085). These findings suggest that total PYY increases only after high-intensity exercise and exhibits a greater responsiveness to SIT compared to moderate-intensity exercise. Compensatory increases in hunger do not seem to occur at any exercise intensity. These findings support a dose-response relationship between exercise intensity and total PYY, though the effects on total GLP-1 and hunger perceptions seem unclear.