کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5045897 1475896 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Number of recent stressful life events and incident cardiovascular disease: Moderation by lifetime depressive disorder
ترجمه فارسی عنوان
تعداد حوادث زندگی روزمره اخیر و بیماری های قلبی عروقی: مداخله با اختلال افسردگی در طول عمر
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


- In a sample of 28,583 U.S. adults, we examined whether number of stressful life events is associated with incident CVD.
- We also examined whether the stressful life events - CVD relationship is stronger in adults with a history of depression.
- Each additional stressful life event was associated with a 15% increased odds of incident CVD.
- Stressful life events and CVD had a stronger association among adults with versus without a lifetime depressive disorder.
- Stressful life events may elevate the risk of new-onset CVD, especially in adults with a history of depression.

ObjectiveWe investigated whether number of recent stressful life events is associated with incident cardiovascular disease (CVD) and whether this relationship is stronger in adults with a history of clinical depression.MethodsProspective data from 28,583 U.S. adults (mean age = 45 years) initially free of CVD who participated in Waves 1 (2001-2002) and 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) were examined. Number of past-year stressful life events (Wave 1), lifetime depressive disorder (Wave 1), and incident CVD (Wave 2) were determined by structured interviews.ResultsThere were 1069 cases of incident CVD. Each additional stressful life event was associated with a 15% increased odds of incident CVD [Odds Ratio (OR) = 1.15, 95% Confidence Interval (CI): 1.11, 1.19]. As hypothesized, a stressful life events by lifetime depressive disorder interaction was detected (P = 0.003). Stratified analyses indicated that stressful life events had a stronger association with incident CVD among adults with (OR = 1.18, 95% CI: 1.10, 1.27, n = 4908) versus without (OR = 1.10, 95% CI: 1.07, 1.14, n = 23,675) a lifetime depressive disorder.ConclusionOur findings suggest that a greater number of recent stressful life events elevate the risk of new-onset CVD and that this risk is potentiated in adults with a history of clinical depression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychosomatic Research - Volume 99, August 2017, Pages 149-154
نویسندگان
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