کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
505417 864501 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A computer model for the simulation of fiber–cell interaction in the alveolar region of the respiratory tract
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نرم افزارهای علوم کامپیوتر
پیش نمایش صفحه اول مقاله
A computer model for the simulation of fiber–cell interaction in the alveolar region of the respiratory tract
چکیده انگلیسی

A mathematical model is presented that describes the health-endangering interaction of fibrous particles deposited in the human alveoli with alveolar fluids, cells, and tissues. As suggested by the theoretical approach, short fibers (diameter: 0.5 μm, length: 2–10 μm) are preferably ingested by alveolar macrophages and removed from the alveolar surface 10–15 days after exposure. Long (diameter: 0.5 μm, length: 10–50 μm) biopersistent fibers are not effectively cleared from the alveoli due to the repeated process of frustrated phagocytosis. Long biosoluble fibers also undergo a frustrated phagocytosis, with processes of extensive lysis leading to their significant shortening. The decrease in length causes the initiation of those clearance mechanisms that are efficient for short fibers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers in Biology and Medicine - Volume 41, Issue 7, July 2011, Pages 565–573
نویسندگان
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