کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5119779 | 1485973 | 2016 | 6 صفحه PDF | دانلود رایگان |
- Gestational alcohol exposure increases pressure-dependent uterine artery constriction.
- Gestational alcohol induces inward hypotrophic remodeling of the uterine artery.
- Binge-alcohol exposure during pregnancy leads to altered uterine arterial adaptations.
We aimed to investigate pressure-dependent maternal uterine artery responses and vessel remodeling following gestational binge alcohol exposure. Two groups of pregnant rats were used: the alcohol group (28.5% wt/v, 6.0Â g/kg, once-daily orogastric gavage in a binge paradigm between gestational day (GD) 5-19) and pair-fed controls (isocalorically matched). On GD20, excised, pressurized primary uterine arteries were studied following equilibration (60Â mm Hg) using dual chamber arteriograph. The uterine artery diameter stabilized at 20Â mm Hg, showed passive distension at 40Â mm Hg, and redeveloped tone at 60Â mm Hg. An alcohol effect (PÂ =Â 0.0025) was observed on the percent constriction of vessel diameter with greater pressure-dependent myogenic constriction. Similar alcohol effect was noted with lumen diameter response (PÂ =Â 0.0020). The percent change in media:lumen ratio was higher in the alcohol group (PÂ <Â 0.0001). Thus, gestational alcohol affects pressure-induced uterine artery reactivity, inward-hypotrophic remodeling, and adaptations critical for nutrient delivery to the fetus.
Journal: Alcohol - Volume 56, November 2016, Pages 59-64