کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5119990 1486115 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparing adult cannabis treatment-seekers enrolled in a clinical trial with national samples of cannabis users in the United States
ترجمه فارسی عنوان
مقایسه درمانگران شاهنامه مبتلا به بالغ در یک کارآزمایی بالینی با نمونه های ملی مصرف کنندگان کانادایی در ایالات متحده
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Substance use disorder study samples are rarely representative of the population.
- This study sample was different from national samples of cannabis users.
- Cannabis treatment studies should work to ensure representative samples.

BackgroundCannabis use rates are increasing among adults in the United States (US) while the perception of harm is declining. This may result in an increased prevalence of cannabis use disorder and the need for more clinical trials to evaluate efficacious treatment strategies. Clinical trials are the gold standard for evaluating treatment, yet study samples are rarely representative of the target population. This finding has not yet been established for cannabis treatment trials. This study compared demographic and cannabis use characteristics of a cannabis cessation clinical trial sample (run through National Drug Abuse Treatment Clinical Trials Network) with three nationally representative datasets from the US; 1) National Survey on Drug Use and Health, 2) National Epidemiologic Survey on Alcohol and Related Conditions-III, and 3) Treatment: Episodes Data Set - Admissions.MethodsComparisons were made between the clinical trial sample and appropriate cannabis using sub-samples from the national datasets, and propensity scores were calculated to determine the degree of similarity between samples.Resultsshowed that the clinical trial sample was significantly different from all three national datasets, with the clinical trial sample having greater representation among older adults, African Americans, Hispanic/Latinos, adults with more education, non-tobacco users, and daily and almost daily cannabis users.ConclusionsThese results are consistent with previous studies of other substance use disorder populations and extend sample representation issues to a cannabis use disorder population. This illustrates the need to ensure representative samples within cannabis treatment clinical trials to improve the generalizability of promising findings.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug and Alcohol Dependence - Volume 176, 1 July 2017, Pages 14-20
نویسندگان
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