کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5120011 | 1486115 | 2017 | 6 صفحه PDF | دانلود رایگان |
- We examined factors underlying smoking maintenance in Major Depression (MD).
- MD+ and MD- smokers completed assessments while smoking as usual and abstinent.
- Sensitivity to negative reinforcement was assessed with a tobacco-seeking task.
- Negative mood and abstinence prime greater tobacco-seeking for MD+ vs. MD- smokers.
- Efficacious treatments should target both mechanisms among MD+ smokers.
BackgroundAlthough depression and smoking commonly co-occur, the mechanisms underpinning this association are poorly understood. One hypothesis is that depression promotes tobacco dependence, persistence and relapse by increasing sensitivity to acute negative mood and abstinence induced tobacco-seeking behavior.MethodsTwenty nine daily smokers of >10 cigarettes per day, nine with major depression and 20 without, completed two laboratory sessions one week apart, smoking as normal prior to session 1 (sated session), and 6 h abstinent prior to session 2 (abstinent session). In both sessions, tobacco-seeking was measured at baseline by preference to view smoking versus food images. Negative mood was then induced by negative ruminative statements and sad music, before tobacco-seeking was measured again at test.ResultsIn the sated session, negative mood induction produced a greater increase in tobacco choice from baseline to test in depressed (p < 0.001, ηp2 = 0.782) compared to non-depressed smokers (p = 0.045, ηp2 = 0.216, interaction: p = 0.046, ηp2=0.150). Abstinence also produced a greater increase in baseline tobacco choice between the sated and abstinent sessions in depressed (p = 0.002, ηp2=0.771) compared to non-depressed smokers (p = 0.22, ηp2 = 0.089, interaction: p = 0.023, ηp2 = 0.189). These mood and abstinence induced increases in tobacco choice were positively associated with depression symptoms across the sample as a whole (ps â¤Â 0.04, ηp2 â¥Â 0.159), and correlated with each other (r = 0.67, p < 0.001).ConclusionsCurrent major depression or depression symptoms may promote tobacco dependence, persistence and relapse by increasing sensitivity to both acute negative mood and abstinence induced tobacco-seeking behavior. Treatments should seek to break the association between adverse states and smoking to cope.
Journal: Drug and Alcohol Dependence - Volume 176, 1 July 2017, Pages 1-6