Higher prevalence of detectable troponin I among cocaine-users without known cardiovascular disease

- We determined associations between cocaine use and cardiac injury.
- Detectable cardiac troponin (cTnI) was higher in cocaine-positive subjects.
- Detectable cTnI was not higher in subjects positive for other drugs.
- Considering cocaine use as a chronic exposure may improve cardiac risk stratification.

BackgroundWhile cocaine use is an established risk factor for acute cardiovascular complications, associations between cocaine use and markers of cardiac injury outside of acute hospital presentation remain poorly characterized. We leveraged advances in cardiac troponin (cTnI) testing to assess low but clinically meaningful levels of cardiac injury among cocaine users and non-users.MethodsWe conducted a case control study comparing cTnI levels by the presence of cocaine among patients presenting for non-cardiac care in an urban safety net hospital. Samples were chosen sequentially among those for which urine drug screens were ordered by providers hospital-wide.ResultsDuring 2015, 14% of all hospital drug screens ordered were cocaine-positive. Among unique persons providing cocaine-positive (N = 100) and cocaine-negative (N = 100) samples, 37% were female, 45% were African-American and the median age was 51. Detectable cTnI (> 0.02 ng/mL) was observed in 21 samples (11%). It was more common in subjects using cocaine (Adjusted OR = 2.81; 95% CI = 1.03-7.65), but not other drugs. Moreover, there was a significant correlation between concentrations of cTnI and the cocaine metabolite, benzoylecgonine (Spearman Correlation = 0.34, p < 0.01).ConclusionsAmong urban safety net hospital patients, 11% had detectable cTnI, and cTnI concentration was significantly correlated with benzoylecgonine concentration. While these preliminary results require additional confirmation, they suggest the potential utility of considering cocaine use as more than just an episodic exposure leading to acute cardiac events. The consideration of cocaine use as an ongoing chronic exposure leading to subclinical cardiac injury may improve risk-stratification and patient outcomes in populations where cocaine use is high.