کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5120116 1486117 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The impact of cannabis and cannabinoids for medical conditions on health-related quality of life: A systematic review and meta-analysis
ترجمه فارسی عنوان
تأثیر کانابیس و کانابینوئید برای شرایط پزشکی بر کیفیت زندگی مرتبط با سلامت: بررسی منظم و متاآنالیز
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Using cannabis/cannabinoids to treat medical conditions is increasingly common.
- The impact on health-related quality of life (HRQoL) remains unclear.
- This systematic review and meta-analysis of studies evaluates the impact on HRQoL.
- Studies showing a positive impact on HRQoL involved subjects with pain symptoms.
- Cannabis studies showed a positive impact on HRQoL than cannabinoids studies.

IntroductionThe use of cannabis or cannabinoids to treat medical conditions and/or alleviate symptoms is increasingly common. However, the impact of this use on patient reported outcomes, such as health-related quality of life (HRQoL), remains unclear.MethodsWe conducted a systematic review and meta-analysis, employing guidelines from Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We categorized studies based on design, targeted disease condition, and type of cannabis or cannabinoid used. We scored studies based on quality and risk of bias. After eliminating some studies because of poor quality or insufficient data, we conducted meta-analyses of remaining studies based on design.ResultsTwenty studies met our pre-defined selection criteria. Eleven studies were randomized controlled trials (RCTs; 2322 participants); the remaining studies were of cohort and cross-sectional design. Studies of cannabinoids were mostly RCTs of higher design quality than studies of cannabis, which utilized smaller self-selected samples in observational studies. Although we did not uncover a significant association between cannabis and cannabinoids for medical conditions and HRQoL, some patients who used them to treat pain, multiple sclerosis, and inflammatory bower disorders have reported small improvements in HRQoL, whereas some HIV patients have reported reduced HRQoL.ConclusionThe relationship between HRQoL and the use of cannabis or cannabinoids for medical conditions is inconclusive. Some patient populations report improvements whereas others report reductions in HRQoL. In order to inform users, practitioners, and policymakers more clearly, future studies should adhere to stricter research quality guidelines and more clearly report patient outcomes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug and Alcohol Dependence - Volume 174, 1 May 2017, Pages 80-90
نویسندگان
, , , ,