کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5130076 1378657 2017 48 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The interplay of two mutations in a population of varying size: A stochastic eco-evolutionary model for clonal interference
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات ریاضیات (عمومی)
پیش نمایش صفحه اول مقاله
The interplay of two mutations in a population of varying size: A stochastic eco-evolutionary model for clonal interference
چکیده انگلیسی

Clonal interference, competition between multiple beneficial mutations, has a major role in adaptation of asexual populations. We provide a simple stochastic model of clonal interference taking into account a wide variety of competitive interactions. The population evolves as a three-type birth-and-death process with type dependent competitions. This allows us to relax the classical assumption of transitivity between mutations, and to predict genetic patterns, such as coexistence of several mutants or emergence of Rock-Paper-Scissors cycles, which were not explained by existing models. In addition, we call into questions some classical preconceived ideas about fixation time and fixation probability of competing mutations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Stochastic Processes and their Applications - Volume 127, Issue 3, March 2017, Pages 701-748
نویسندگان
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