کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5131454 | 1491309 | 2017 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gas chromatography tandem mass spectrometry offers advantages for urinary steroids analysis
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Gas chromatography mass spectrometry has been the lynchpin of clinical assessment of steroid profiles for â¼3 decades. The improvements in assay performance offered by tandem mass spectrometry were assessed. Across the spectrum of glucocorticoid and androgen analytes tested, limits of detection and quantitation were â¼20 fold lower with triple than single quadrupole systems, but the more noticeable improvement was that signal to noise was substantially improved and the linear range wider. These benefits allowed more reliable and concomitant measurement of steroids with substantially different abundances and in smaller volumes of urine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytical Biochemistry - Volume 538, 1 December 2017, Pages 34-37
Journal: Analytical Biochemistry - Volume 538, 1 December 2017, Pages 34-37
نویسندگان
Natalie Homer, Sanjay Kothiya, Alison Rutter, Brian R. Walker, Ruth Andrew,