کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5131766 | 1491333 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Selective, switchable fluorescent probe for heparin based on aggregation-induced emission
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Selective, switchable fluorescent probe for heparin based on aggregation-induced emission Selective, switchable fluorescent probe for heparin based on aggregation-induced emission](/preview/png/5131766.png)
چکیده انگلیسی
A positively charged tetraphenylethene (TPE) derivative, TPE-4MN, was synthesized as a probe for heparin based on aggregation induced emission. On the addition of 5.0 μg/mL of heparin, TPE-4MN showed an enhanced emission of about 10-fold. The change in fluorescence at 475 nm was linear over a range of heparin concentrations of 0-1.0 μg/mL with an R = 0.99988 and the limit of detection (LOD) was calculated to be 0.75 μg/mL. The mechanism of the detection was proven to be through an ion pairing interaction. TPE-4MN showed good selectivity for heparin over other types of polysaccharides and could easily distinguish heparin from heparan sulfate, a glycosaminoglycan having a similar structure to that of heparin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytical Biochemistry - Volume 514, 1 December 2016, Pages 48-54
Journal: Analytical Biochemistry - Volume 514, 1 December 2016, Pages 48-54
نویسندگان
Yi Jia Wang, Lei Lin, Xing Zhang, Victor Schultz, Fuming Zhang, Jing Zhi Sun, Robert J. Linhardt,