کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5142040 | 1496021 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Alpha-glucosidase and carbonic anhydrase inhibition studies of Pd(II)-hydrazide complexes
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Alpha-glucosidase and carbonic anhydrase inhibition studies of Pd(II)-hydrazide complexes Alpha-glucosidase and carbonic anhydrase inhibition studies of Pd(II)-hydrazide complexes](/preview/png/5142040.png)
چکیده انگلیسی
This study focused on the synthesis and characterization of hydrazide ligands and their respective Pd(II) complexes and used high throughput screening to determine their α-glucosidase and carbonic anhydrase II enzyme inhibition activities. The physical, analytical (elemental analyses for C, H, N and Pd) and spectral (FT-IR, 1H NMR, 13C NMR, EI-mass) techniques utilized during characterization revealed the formation of square planar, neutral and 1:2 Pd(II)-hydrazide complexes with the general formula [PdL2Cl2]. In these Pd(II) complexes, the hydrazide ligands are monodentate; the terminal nitrogen is the donor atom. The uncoordinated hydrazide ligands were inactive against both α-glucosidase and carbonic anhydrase II enzymes; however, the respective Pd(II)-hydrazide complexes were approximately 300 times more potent α-glucosidase inhibitors than the standard compound, 1-deoxynojirimycin (DNJ). Some of the Pd(II) complexes also demonstrated potential carbonic anhydrase (CA) inhibition properties comparable to the standard compound, acetazolamide (ACZ).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Arabian Journal of Chemistry - Volume 10, Issue 4, May 2017, Pages 488-499
Journal: Arabian Journal of Chemistry - Volume 10, Issue 4, May 2017, Pages 488-499
نویسندگان
Qurrat-ul-Ain Qurrat-ul-Ain, Uzma Ashiq, Rifat Ara Jamal, Muhammad Saleem, Mohammad Mahroof-Tahir,