کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5142467 | 1496034 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A modified high-performance liquid chromatographic method for the analysis of pantoprazole sodium in pharmaceutical dosage forms using lansoprazole as internal standard
ترجمه فارسی عنوان
یک روش کروماتوگرافی مایع با کارایی بالا برای تجزیه و تحلیل پانوترازول سدیم در فرمهای دارویی با استفاده از لانزوپرازول به عنوان استاندارد داخلی
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کلمات کلیدی
پانتوپراازول سدیم، کروماتوگرافی مایع فرم داروی دارویی،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
چکیده انگلیسی
A Simple and rapid reversed-phase high-performance liquid chromatographic method for the direct determination of pantoprazole in pharmaceutical dosage forms was developed and validated. Lansoprazole was used as internal standard. The chromatographic separation of pantoprazole and lansoprazole was achieved on a Nucleodur C8 column (250 Ã 4.6 mm i.d., 5 μm particle size) using the photodiode array detector at 280 nm. The optimized mobile phase was consisted of a mixture of 0.1 M ammonium acetate solution and methanol (42:58, v/v), pumped at a flow rate 1.0 mL minâ1. The retention times for pantoprazole and lansoprazole were 8.10 and 11.15 min, respectively. Linearity range was 3.06-1243.0 μg mLâ1 with limit of detection value of 0.78 μg mLâ1. The precision of the method was demonstrated using intra- and inter-day assay RSD% values which were less than 2.07%, while the recovery was 99.07-103.95%. No interference from any components of pharmaceutical dosage forms or degradation products was observed. According to the validation results, the proposed method was found to be specific, accurate, precise and could be applied to the quantitative analysis of pantoprazole in tablets.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Arabian Journal of Chemistry - Volume 9, Supplement 1, September 2016, Pages S114-S119
Journal: Arabian Journal of Chemistry - Volume 9, Supplement 1, September 2016, Pages S114-S119
نویسندگان
Safwan Ashour, Soulafa Omar,