Synthesis, characterization and pharmacological screening of novel benzimidazole derivatives

In present study o-phenylenediamine and phenoxyacetic acid were used as starting material through series of steps 2-[2-(phenoxymethyl)-1H-benzimidazol-1-yl]acetohydrazide 5 was obtained. Various derivatives of 2-[2-(phenoxymethyl)-1H-benzimidazol-1-yl]-N′-[(Z)-phenylmethylidene]acetohydrazide and some compounds containing oxadiazole bearing benzimidazole were synthesized by using various aromatic aldehyde, cyanogens bromide and carbon disulfide/potassium hydroxide. These were elucidated by IR, NMR and elemental analysis and their in vivo anticonvulsant screening was performed using MES and scPTZ. Two compounds 7g and j were found to be potent in both the screens and their protective index was found to be better than standard drugs used.