کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5142528 | 1496034 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation and evaluation of molecularly imprinted polymer liquid chromatography column for the separation of ephedrine enantiomers
ترجمه فارسی عنوان
آماده سازی و ارزیابی ستون کروماتوگرافی مایع پلیمری مولکولی برای جداسازی آنتی آمین های افدرین
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کلمات کلیدی
انانتیومرها، افدرین، داروهای کریل، پلیمرهای مونومر شده قالب،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
چکیده انگلیسی
In this study molecular imprinting technology was employed to prepare a specific affinity sorbent for the resolution of Ephedrine, a chiral drug. The molecularly imprinted polymer (MIP) was prepared by non-covalent molecular imprinting with either (+) or (-)-Ephedrine ((Râ,Sâ)-2-(methylamino)-1-phenylpropan-1-ol) as the template. Methacrylic acid and ethylene glycol di-methacrylate were copolymerized in the presence of the template molecule. The bulk polymerization was carried out in chloroform with 2,2â²-azobisisobutyronitrile as the initiator, at 5°C and under UV radiation. The resulting MIP was ground into powders, which were slurry packed into analytical columns. After removal of template molecules, the MIP-packed columns were found to be effective for the resolution of (±)-Ephedrine racemates. The separation factor for the enantiomers ranged between 1.3 and 2.1 when the column was packed with MIP prepared with (+)-Ephedrine as the template. A separation factor ranging from 1.3 to 2.6 could be achieved from the column packed with MIP, prepared with (-)-Ephedrine as the template. Although the separation factor was higher with that previously obtained from reversed-phase column chromatography following derivatization with a chiral agent, elution peaks were broader due to the heterogeneity of binding sites on the MIP particles and the possible non-specific interaction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Arabian Journal of Chemistry - Volume 9, Supplement 1, September 2016, Pages S528-S536
Journal: Arabian Journal of Chemistry - Volume 9, Supplement 1, September 2016, Pages S528-S536
نویسندگان
Krishnamoorthy balamurugan, Kannan Gokulakrishnan, Tangirala Prakasam,