Synthesis and structure-activity relationships study of α-aminophosphonate derivatives containing a quinoline moiety

Two series of α-aminophosphonate derivatives containing a quinoline moiety have been designed, synthesized and evaluated for cytotoxic activity against Eca109 and Huh7 cancer cell lines in vitro. Among them, compounds 4b2 and 4b4 were found to be more active than Sunitinib against both of two cancer cell lines.