Study of the synthesis, antiviral bioactivity and interaction mechanisms of novel chalcone derivatives that contain the 1,1-dichloropropene moiety

A series of chalcone derivatives that contain the 1,1-dichloropropene moiety was synthesized and assayed for the antiviral activity against tobacco mosaic virus. Compound 7h showed significant inactivation activity against TMV and strong interaction with the tobacco mosaic virus coat protein.