Palladium-catalyzed amination of chloro-substituted 5-nitropyrimidines with amines

Chloro-substituted 5-nitropyrimidines are synthesized using a palladium-catalyst method and has proved the generality of this reaction system. A series of mono-substituted and di-substituted 5-nitropyrimidines are synthesized with a high yield, which can act as the important intermediates of pharmaceutical nucleosides and purines.