Synthesis and biological activities of (E)-β-farnesene analogues containing 1,2,3-thiadiazole

A series of novel (E)-β-farnesene analogues containing 1,2,3-thiadiazole were designed and synthesized by replacing unstable conjugated double bond of (E)-β-farnesene with1,2,3-thiadiazole ring. They are not only exhibited good stability but also showed strong repellent effects and aphicidal activities compared to the lead (E)-β-farnesene.