Effect of chirality on conformation and cellular uptake of poly(S-(o-nitrobenzyl)-l,d-cysteine) polypeptides

A series of poly(S-(o-nitrobenzyl)-l,d-cysteine) polypeptides with different chirality was synthesized and their molecular structures, secondary conformations, drug release and biological properties were thoroughly investigated. The chirality of the polypeptides had effect on secondary conformations and the cellular uptake behavior of the related nanoparticles.