Design, synthesis and biological evaluation of substituted aminopyridazin-3(2H)-ones as G0/G1-phase arresting agents with apoptosis-inducing activities

In this paper, Novel (2-(2-methoxyphenoxy)ethyl)aminopyridazin-3(2H)-one derivatives bearing substituted benzyl groups were designed and synthesized. Among these compounds, compounds 8a-b exhibited wonderful antiproliferative activities against SH-SY5Y cells, and induced apoptosis and G0/G1-phase cell cycle arrest in human SH-SY5Y cells in a dose-dependent manner.154