Synthesis and biological evaluation of novel 6,11-dihydro-5H-benzo[e]pyrimido- [5,4-b][1,4]diazepine derivatives as potential c-Met inhibitors

A series of novel 6,11-dihydro-5H-benzo[e]pyrimido[5,4-b] [1,4]diazepine derivatives were designed, synthesised and evaluated for their c-Met kinase inhibition. The promising compound 17f displayed favourable pharmacokinetic properties, an acceptable safety profile, and significant anti-tumour activity in the Caki-1 tumour xenograft model.72