Identification of thiazolo[5,4-d]pyrimidine derivatives as potent antiproliferative agents through the drug repurposing strategy

A series of thiazolo[5,4-d]pyrimidine derivatives were designed through the drug repurposing strategy. Compound 24 displayed high potency and selectivity against MGC-803 cells, and induced the apoptosis of MGC-803 cells.170