کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5158354 | 1501086 | 2017 | 57 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design, synthesis, biological evaluation, molecular docking and QSAR studies of 2,4-dimethylacridones as anticancer agents
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Design, synthesis, biological evaluation, molecular docking and QSAR studies of 2,4-dimethylacridones as anticancer agents Design, synthesis, biological evaluation, molecular docking and QSAR studies of 2,4-dimethylacridones as anticancer agents](/preview/png/5158354.png)
چکیده انگلیسی
Multidrug resistance in cancer is an unmet challenge and drawback for the failure of many chemotherapeutic drugs. Search for targeted, effective drug with minimum toxicity is an urgent need. An attempt has been made to explore the chemosensitizing ability of 2,4-dimethylacridones with alkyl side chain containing substituting tertiary amines at the end of the side chain. Considering the structural features required for the MDR reversal activity, 2,4-dimethylacridone with propyl and butyl side chain containing various tertiary amino groups like morpholinyl, piperidinyl, N-methyl piperazinyl, N,N-diethylamino, N-diethanolamino, β-hydroxylethyl piperazino at the terminus of the alkyl side chain have been synthesized, characterized and screened for anticancer and MDR modulation activity.147
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 130, 21 April 2017, Pages 154-170
Journal: European Journal of Medicinal Chemistry - Volume 130, 21 April 2017, Pages 154-170
نویسندگان
Manikanta Murahari, Prashant S. Kharkar, Nitin Lonikar, YC Mayur,