Design, synthesis and characterization of novel quinacrine analogs that preferentially kill cancer over non-cancer cells through the down-regulation of Bcl-2 and up-regulation of Bax and Bad

The present study describes the design, synthesis, and examination of 23 novel quinacrine derivatives generated by the hybridization of the quinacrine core scaffold and thiazolidin-4-ones in an attempt to develop effective and selective anticancer agents.149