Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies

Three different series of novel sulfonamides incorporating substituted indolin-2-one moieties linked to benzenesulfonamide through aminoethyl or (4-oxothiazolidin-2-ylidene)aminoethyl linkers, were synthesized and evaluated for their inhibitory activity against a panel of carbonic anhydrase isoforms, hCA I, II, IV and VII.247