کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5158708 1501078 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New arylpyrazoline-coumarins: Synthesis and anti-inflammatory activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
New arylpyrazoline-coumarins: Synthesis and anti-inflammatory activity
چکیده انگلیسی
New arylpyrazole-coumarins with anti-inflammatory activity were designed and synthesized. Among them, compound 4m showed the highest anti-inflammatory activity with inhibiting IL-6, TNF-α and NO production LPS-stimulated. The further study showed that title compound could significantly suppress LPS-induced iNOS, COX-2 expression and IL-6, TNF-α, NO production through NF-κB/MAPK signaling pathway.193
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 138, 29 September 2017, Pages 170-181
نویسندگان
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