Azide-alkyne cycloaddition towards 1H-1,2,3-triazole-tethered gatifloxacin and isatin conjugates: Design, synthesis and in vitro anti-mycobacterial evaluation

A new class of 1H-1,2,3-triazole-tethered gatifloxacin isatin conjugates (MIC: 0.10-8 μg/mL) with greater lipophilicity compared with gatifloxacin exhibited excellent inhibitory activity against MTB H37Rv and MDR-TB.137