کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5158887 | 1501090 | 2017 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors](/preview/png/5158887.png)
چکیده انگلیسی
A series of novel non-covalent piperazine or piperidine-containing dipeptidyl derivatives possessing a neopentyl-asparagine residue, as exemplified by compound 35, were designed and synthesized. Most of the target compounds exhibited potent in vitro, ex vivo and in vivo proteasome inhibitory activities and anti-proliferation activities against two multiple myeloma cell lines. Additionally, the enzymatic stability of target compound was also improved.193
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 126, 27 January 2017, Pages 1056-1070
Journal: European Journal of Medicinal Chemistry - Volume 126, 27 January 2017, Pages 1056-1070
نویسندگان
Rangxiao Zhuang, Lixin Gao, Xiaoqing Lv, Jianjun Xi, Li Sheng, Yanmei Zhao, Ruoyu He, Xiaobei Hu, Yidan Shao, Xuwang Pan, Shourong Liu, Weiwei Huang, Yubo Zhou, Jia Li, Jiankang Zhang,