کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
517586 867467 2007 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Precedence Temporal Networks to represent temporal relationships in gene expression data
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نرم افزارهای علوم کامپیوتر
پیش نمایش صفحه اول مقاله
Precedence Temporal Networks to represent temporal relationships in gene expression data
چکیده انگلیسی

The reconstruction of gene regulatory networks from gene expression time series is nowadays an interesting research challenge. A key problem in this kind of analysis is the automated extraction of precedence and synchronization between interesting patterns assumed by genes over time.The present work introduces Precedence Temporal Networks (PTN), a novel method to extract and visualize temporal relationships between genes. PTNs are a special kind of temporal network where nodes represent temporal patterns while edges identify precedence or synchronization relationships between the nodes.The method is tested on two case studies: the expression of a subset of genes in the soil amoeba Dictyostelium discoideum and of a set of well-studied genes involved in the human cell cycle regulation. The extracted networks reflect the capability of the algorithm to clearly reconstruct the timing of the considered gene sets, highlighting different stages in Dictyostelium development and in the cell cycle, respectively.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomedical Informatics - Volume 40, Issue 6, December 2007, Pages 761–774
نویسندگان
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