کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
518185 867565 2014 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Boundary control of bidomain equations with state-dependent switching source functions in the ionic model
ترجمه فارسی عنوان
کنترل مرزی معادلات بیدمن با توابع منبع سوئیچ وابسته به حالت در مدل یونی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نرم افزارهای علوم کامپیوتر
چکیده انگلیسی

Optimal control for cardiac electrophysiology based on the bidomain equations in conjunction with the Fenton–Karma ionic model is considered. This generic ventricular model approximates well the restitution properties and spiral wave behavior of more complex ionic models of cardiac action potentials. However, it is challenging due to the appearance of state-dependent discontinuities in the source terms. A computational framework for the numerical realization of optimal control problems is presented. Essential ingredients are a shape calculus based treatment of the sensitivities of the discontinuous source terms and a marching cubes algorithm to track iso-surface of excitation wavefronts. Numerical results exhibit successful defibrillation by applying an optimally controlled extracellular stimulus.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Computational Physics - Volume 273, 15 September 2014, Pages 227–242
نویسندگان
, , ,