کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5348816 1503636 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Construction of mussel-inspired coating via the direct reaction of catechol and polyethyleneimine for efficient heparin immobilization
ترجمه فارسی عنوان
ساخت پوشش الهام گرفته از موی سرخ از طریق واکنش مستقیم کاتچول و پلی اتیلنیمین برای بی تحرکی کارآمد هپارین
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
چکیده انگلیسی
Dopamine could self-polymerize to form the coating on various substrates and the co-existence of catechols and amines was crucial in performing such polymerization process. In this work, a mimetic approach of coating formation was carried out based on the co-polymerization of catechol (CA) and polyethyleneimine (PEI). Mussel-inspired CA/PEI coating was deposited on 316L stainless steel (SS). Fourier transform infrared spectra (FTIR) and X-ray photoelectron spectroscopy (XPS) demonstrated the successful coating formation. QCM measurement showed good affinity of heparin immobilization on CA/PEI coating surface ascribed to the amine groups. Herein, vascular cell-material interactions like endothelial cells (ECs) and smooth muscle cells (SMCs) were also investigated. Interestingly, CA/PEI and heparin modified coatings presented no cytotoxicity to ECs, however to a certain extent, decreased SMCs proliferation. Moreover, heparin-binding surface presented significant anti-platelet adhesion and activation properties. These results effectively suggested that the mussel-inspired CA/PEI coating might be promising when served as a platform for biomolecule immobilization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Surface Science - Volume 328, 15 February 2015, Pages 163-169
نویسندگان
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