کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5348863 | 1503636 | 2015 | 39 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hydroxyapatite nanocrystals functionalized with alendronate as bioactive components for bone implant coatings to decrease osteoclastic activity
ترجمه فارسی عنوان
نانوبلورهای هیدروکسی آپاتیت با آلندرونات به عنوان اجزای فعال زیست محیطی برای پوشش های ایمپلنت استخوانی برای کاهش فعالیت استئوکلاستیک
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کلمات کلیدی
پوشش بیسفسفونات، استئوکلاست، پوکی استخوان، هیدروکسی آپاتیت، الکترو اسپری،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
چکیده انگلیسی
The integration of bone implants within native bone tissue depends on periprosthetic bone quality, which is severely decreased in osteoporotic patients. In this work, we have synthesized bone-like hydroxyapatite nanocrystals (nHA) using an acid-base neutralization reaction and analysed their physicochemical properties. Subsequently, we have functionalized the nHA with alendronate (nHAALE), a well-known bisphosphonate drug used for the treatment of osteoporosis. An in vitro osteoclastogenesis test was carried out to evaluate the effect of nHAALE on the formation of osteoclast-like cells from monocytic precursor cells (i.e. RAW264.7 cell line) showing that nHAALE significantly promoted apoptosis of osteoclast-like cells. Subsequently, nHA and nHAALE were deposited on titanium disks using electrospray deposition (ESD), for which characterisation of the deposited coatings confirmed the presence of alendronate in nHAALE coatings with nanoscale thickness of about 700Â nm. These results indicate that alendronate linked to hydroxyapatite nanocrystals has therapeutic potential and nHAALE can be considered as an appealing coating constituent material for orthopaedic and oral implants for application in osteoporotic patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Surface Science - Volume 328, 15 February 2015, Pages 516-524
Journal: Applied Surface Science - Volume 328, 15 February 2015, Pages 516-524
نویسندگان
Ruggero Bosco, Michele Iafisco, Anna Tampieri, John A. Jansen, Sander C.G. Leeuwenburgh, Jeroen J.J.P. van den Beucken,