The research and preparation of a novel nano biodegradable polymer external reinforcement

► The drug loaded vascular external graft was synthesized with electrospinning scaffolds and triblock copolymer micelles. ► GPG micelles may influence cell differentiation when concentration exceed 20 μg/mL. ► The micelles coated electrospinning scaffolds provided good support for cell growth under the percentages 10% w/w% (GPG:PLCL-fibrinogen). ► Micelles coated electrospinning scaffold have a great potential for vascular tissue engineering application in the future.