Targeted delivery and pH-responsive release of stereoisomeric anti-cancer drugs using β-cyclodextrin assemblied Fe3O4 nanoparticles

- β-Cyclodextrin assemblied magnetic Fe3O4 nanoparticles (β-CD-MNPs) with good stability were successfully fabricated.
- Stereoisomeric doxorubicin (DOX) and epirubicin (EPI) were used to explore the loading and release performance.
- The loading properties of β-CD-MNPs were investigated using the Langmuir and Freundlich adsorption equilibrium models.
- 1H NMR and the computer simulation were used to demonstrate the inclusion position between drug molecules and β-CD.