Enhancement of growth and osteogenic differentiation of MC3T3-E1 cells via facile surface functionalization of polylactide membrane with chitooligosaccharide based on polydopamine adhesive coating

â¿¢COS was conveniently immobilized on PDLLA membrane based on PDOPA adhesive layer.â¿¢The hydrophilicity of PDLLA membrane was improved by modified with PDOPA and COS.â¿¢COS-functionalized PDLLA membrane is favorable to cell adhesion and proliferation.â¿¢COS-coated PDLLA membrane notably promote osteogenic differentiation of MC3T3-E1.