Protein photoimmobilizations on the surface of quartz glass simply mediated by benzophenone

► The main intention of this manuscript is to photoimmobilize protein on the surface of quartz glass through a simple and effective way. ► Protein photo-immobilizations on glass surface simply using BP as a photochemical linker were realized by three different methods in this paper. ► Three different photoinduced methods were compared in respect of immobilization density, coverage homogeneities and photo-localization. ► The appealing characters will be of interests for industrial applications in silicon-based fields, including chips, sensors, etc.