Integrating sol-gel with cold plasmas modified porous polycaprolactone membranes for the drug-release of silver-sulfadiazine and ketoprofen

► Integrated control-release system of sol-gel and biodegradable polycaprolactone membrane. ► Biocompatible and nontoxic chitosan-SiO2 sol-gel for drug loading. ► Characterizations of the oxygen plasma modified biodegradable PCL porous membrane. ► Achieved controllable in vitro release for ketoprofen and silver sulfadiazine. ► The sol-gel/plasma modified porous membranes showed excellent biocompatibility.