Preparation of Ag nanoparticle dispersed silk fibroin compact

► We reported the facile synthesis of Ag-nanoparticle (Ag-NP) dispersed silk fibroin compact. ► The fibroin protein itself served as the reducing agent for AgNO3. ► Ag NPs dispersed silk compact exhibited a characteristic color, corresponding to the surface plasmon resonance of Ag NPs. ► Ag NPs did not affect the thermal stability of silk fibroin. ► The antimicrobial test indicated that Ag-NPs dispersed silk compact have an excellent antimicrobial activity.